Take I-95 South into Chester and exit at Rte 322 West. Take Route 322 West to Route 1 and turn right onto Route 1 North. Turn left at the light onto Cheyney Road. Go past Delaware Valley Prison. Turn right onto the first road past the prison, Glen Mills Road. The school is on the left, about 1 mile.
With Holy Ghost Prep art teacher Karen Smallen set to retire after 26 years of excellence at the school, here's a feature that Matt Jordan, an English teacher at HGP, wrote about her in the Winter issue of Holy Ghost Prep Magazine.